Abraham M. Lenhoff
Education
- Doctorate - 1984 University of Wisconsin-Madison
- Masters - 1979 University of Wisconsin-Madison
- Bachelors - 1976 University of Cape Town, South Africa
"The main goal of our research is to analyze, control and exploit molecular interactions involving proteins and colloidal particles. The motivation is initially to obtain improved quantitative insights into existing processes, leading to more effective methods for designing and using them, but an auxiliary objective is to develop new products and operations. These themes bring together a diverse collection of research activities, discussed below, involving theoretical and experimental work dealing with both the fundamentals -- transport, kinetic and thermodynamic phenomena -- and their interaction in the process environment. The path from molecular structure through continuum properties to process design represents the central paradigm in modern chemical engineering, but it has been applied much less extensively to species such as proteins than to small molecules; such processes as protein separations still depend very heavily on empirical methods for design and optimization."
Selected Publications
For a complete listing of publications, please view the Full CV.
- Velev, O. D., Y. H. Pan, E. W. Kaler and A. M. Lenhoff, "Molecular Effects of Anionic Surfactants on Lysozyme Precipitation and Crystallization", Cryst. Growth Des. 5, 351, (2005)
- Vivares, D., E. W. Kaler and A. M. Lenhoff, "Quantitative Imaging by Confocal Scanning Fluorescence Microscopy of Protein Crystallization via Liquid-Liquid Phase Separation", Acta Cryst. 61, 724, (2005)
- Berger, B. W., C. M. Gendron, C. R. Robinson, E. W. Kaler and A. M. Lenhoff, "The Role of Protein and Surfactant Interactions in Membrane Protein Crystallization", Acta Cryst. 61, 819, (2005)
- Berger, B. W., R. Y. Garcia, A. M. Lenhoff, E. W. Kaler and C. R. Robinson, "Relating Surfactant Properties to Activity and Solubilization of the Human Adenosine A3 Receptor", Biophys. J. (2005)
- Yao, Y., and A. M. Lenhoff, "Electrostatic Contributions to Protein Retention in Ion-Exchange Chromatography. II. Proteins with Various Degrees of Structural Differences", Anal. Chem. 77, 2157, (2005)
- Asthagiri, D., A. Paliwal, D. Abras, A. M. Lenhoff and M. E. Paulaitis, "A Consistent Experimental and Modeling Approach to Light Scattering Studies of Protein-Protein Interactions in Solution", Biohphys. 88, 3300, (2005)
- Berger, B. W., C. J. Blamey, U. P. Naik, B. J. Bahnson and A. M. Lenhoff, "The Roles of Additives and Precipitants in Crystallization of Calcium- and Integrin-Binding Protein", Cryst. Growth Des. (2005)
- Tessier, P. M., V. J. Verruto, S. I. Sandler and A. M. Lenhoff, "Correlation of Diafiltration Sieving Behavior of Lysozyme-BSA Mixtures with Osmotic Second Virial Cross Coefficients", Biotech. Bioeng. 87, 303, (2004)
- P. M. Tessier and A. M. Lenhoff, "Measurements of Protein Self-Association as a Rational Guide to Crystallization", Curr. Opin. Biotech. 14, 512, (2004)
- P. DePhillips and A. M. Lenhoff, "Relative Retention of FGF-1 and FGF-2 on Strong Cation Exchange Adsorbents", J. Chrom. A 1036, 51, (2004)
Patents
Selected Awards
For a complete listing of awards, please view the Full CV.
- Gore Professorship in Chemical Engineering: 2002
- Weissberger-Williams Lecturer, Eastman Kodak Co.: 2000
- College of Engineering Special Faculty Award: 1991
- NSF Presidential Young Investigator Award: 1987
- Research Fellowship, Alexander von Humboldt-Stiftung: 1985
- S. A. Institution of Chemical Engineers Medal: 1976
- D. N. Malan Medals in Chemical Engineering
- Cape Town Corporation Medals in Engineering
