Prasad S Dhurjati

Prasad Dhurjati
  • Joint Professor, Mathematical Sciences
  • Professor

267 CLB
University of Delaware
Newark, Delaware 19716
302-831-1048 (fax)

  • Doctorate - 1982 Purdue University
  • Bachelors - 1977 Indian Institute of Technology, Kanpur, India

"Our current research combines four decades of expertise in biotechnology and artificial intelligence. This research has resulted in over a hundred publications that have been cited more than 3100 times with a H-index of 31 and an i10 index of 56. The top five papers have been cited over 1100 times. The research has also resulted in the training of nearly 40 graduate students and post-doctoral research fellows (currently well-placed in industry and academia) and over 100 undergraduate research students. Current research is in the area of Systems Biology, Systems Medicine and Modeling of Engineering Systems. In biotechnology, we are applying mathematical models and knowledge-based approaches to convert biological and medical data to useful knowledge.

Our past experimental research in biotechnology (1977-2000) has resulted in a better understanding of microscopic and macroscopic variables that influence the kinetics of genetically engineered microorganisms. In joint research with the Pasteur Institute in Paris, we examined the effect of gene sequence and protein structure on the mechanism of inclusion body (protein aggregate) formation. As part of collaborative research with DuPont in environmental biotechnology, we investigated the use of bioluminescent recombinant microorganisms as sensors for pollutants.

A second major area of our past research was in Knowledge-Based Process Monitoring and Fault Diagnosis. In a joint project with Foxboro and DuPont (1982-86), we were involved in a pioneering effort for the first industrial application of an expert system, FALCON (Fault Analysis Consultant), for on-line fault diagnosis in a dynamic chemical process (DuPont adipic acid plant in Victoria, Texas).

Recent research activity has been in the Biotransformation of Coal to Methane using a community of microorganisms. We are examining the biodegradation of coal using lumped kinetic models to assist us in improving commercial scale Coal Bed Methane (CBM) processes via microbial enhancement.

We are currently combining our past expertise in biotechnology and knowledge-based systems to examine novel applications in Systems Biology and Systems Medicine. A major area of focus is the relationship between the gut microbiome and imbalances in the physiological system. In the area of Systems Medicine, we are looking at the effect of the human microbiome on health and diseases. We have recently developed a systems connectivity model of Autism Spectrum Disorders (ASD) and also followed up with mathematical models and artificial intelligence or agent-based models of ASD. We have also developed Physiology-Based PharmacoKinetic (PBPK) models to understand the distribution of various drugs in the human body including calculating dosages for nanoparticle delivery in leukemia therapy, dosages for osteoporosis, and for lithium in bipolar disorder. More recently, we have developed a rule-based model for how glioblastoma cells move and spread in brain cancer."

XSelected Publications

For a complete listing of publications, please view the Full CV.
  1. Dhurjati, P., D. Ramkrishna, M. C. Flickinger and G. T. Tsao, "A Cybernetic View of Microbial Growth: Modeling of Cells as Optimal Strategists", Biotechnology and Bioengineering 27, 1, (1985)
  2. Petti, T. F., J. Klein and P. Dhurjati, "The Diagnostic Model Processor - Using Deep Knowledge for Process Fault Diagnosis", AIChE Journal 36 (4), 565, (1990)
  3. Van Dyk, Tina K., W. R. Majarian, K. B. Konstantinov, R. M. Young, P. Dhurjati and R. LaRossa, "Rapid and sensitive pollutant detection by induction of heat shock gene-bioluminescence gene fusions", Applied and Environmental Microbiology 60 (5), 1414, (1994)
  4. Chen Z.C, Nora C. Beck-Tan, P. Dhurjati, T. K. van Dyk, R. A. LaRossa, S. L. Cooper, "Quaternary Ammonium Functionalized Poly (propylene imine) Dendrimers as Effective Antimicrobials: Structure-Activity Studies", Biomacromolecules 1, 473-480, (2000)
  5. P. Dhurjati and R. Mahadevan, "Systems Biology: The synergistic interplay between biology and mathematics", Invited Lead Review article, Canadian Journal of Chemical Engineering 86, 127-141, (2008)
  6. Colin Heberling, Prasad Dhurjati and Myron Sasser, "Hypothesis for a systems connectivity model of autism spectral disorder pathogenesis: Link to gut bacteria, oxidative stress and intestinal permeability", Medical Hypotheses 80, 264-270, (2013)
  7. Sean G. Mack, Daniel J. Cook, Prasad Dhurjati, Matthew E. R. Butchbach, "Systems Biology Investigation of cAMP Modulation to increase SMN levels for the Treatment of Spinal Muscular Atrophy", PLOS One 9(12), (2014)
  8. Bronson Weston, Benjamin Fogal, Daniel Cook, Prasad Dhurjati, "An agent-based modeling framework for evaluating hypotheses on risks for developing autism: Effects of the gut microbial environment", Medical Hypotheses (2015)
  9. A. Lisberg, R. Ellis, K. Nicholson, P. Moku, A. Swarup, P. Dhurjati, A. Nohe, "Mathematical Modeling of the Effects of CK2.3 on Mineralization in Osteoporotic Bone", CPT Pharmacometrics & Systems Pharmacology 6, 208, (2017)
  10. J. Caccavle, D. Fiumara, M. Stapf, L. Sweitzer, H.J. Anderson, J. Gorky, P. Dhurjati and D.S. Galileo, "A simple and accurate rule-based modeling framework for simulation of autocrine/paracrine stimulation of glioblastoma cell motility and proliferation by L1CAM in 2-D culture", BMC Systems Biology 11: 124, (2017)


XSelected Awards

For a complete listing of awards, please view the Full CV.
  1. NSF Presidential Young Investigator Award: 1986 - 1991
  2. College of Engineering Special Faculty Award
  3. Elected Fellow, American Institute of Medical and Biological Engineering

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