Prasad S Dhurjati
- Full Professor
University of Delaware
Newark, Delaware 19716
- Doctorate - 1982 Purdue University
- Bachelors - 1977 Indian Institute of Technology, Kanpur, India
"Our current research combines three decades of expertise in biotechnology and artificial intelligence. This research has resulted in over a hundred publications that have been cited over 2300 times with a H-index of 25. The top ten papers have been cited over 1000 times. The research has also resulted in the training of nearly 40 graduate students and post-doctoral research fellows (who are currently well placed in industry and academia) and over 80 undergraduate research students. The key research accomplishments are in the fields of Biochemical engineering and ?On-line fault diagnosis?. Current research is in the area of Systems Biology, Systems Medicine and Modeling of Engineering Systems. In biotechnology, we are currently applying mathematical models and knowledge-based approaches to convert biological and medical data to useful knowledge.
Our past research in biotechnology has resulted in a better understanding of microscopic and macroscopic variables that influence the kinetics of genetically engineered microorganisms. In joint research with the Pasteur Institute in Paris, Kostas Tokatlidis examined the effect of gene sequence and protein structure on the mechanism of inclusion body (protein aggregate) formation. The papers from this work were cited nearly 300 times. As part of collaborative research with DuPont in environmental biotechnology, Konstantin Konstantinov (DuPont/Delaware) investigated the use of bioluminescent recombinant microorganisms as sensors for pollutants. The related paper has been cited 250 times.
A second major area of our research is Knowledge-Based Process Monitoring and Fault Diagnosis. In a joint project with Foxboro and DuPont (1982-86), we were involved in a pioneering effort for the first industrial application of an expert system, FALCON (Fault Analysis Consultant), for on-line fault diagnosis in a dynamic chemical process (DuPont adipic acid plant in Victoria, Texas).
We are currently combining our past expertise in biotechnology and knowledge-based systems to examine novel applications in Systems Biology and Systems Medicine. In the area of Systems Medicine, we are looking at the effect of the human microbiome on health and diseases. We have recently developed a systems connectivity model of Autism) and also followed up with mathematical models and artificial intelligence or agent-based models of Autism. We are also building a lab-scale artificial gut reactor to simulate the microbial dynamics in the gut microbiome. Our goal is to develop system level models and tools for analysis and integration of information at various levels of hierarchy in biological and medical systems. Our review article on Systems Biology (April 2008) points to the future direction of our research. We have also developed Physiology-Based PharmacoKinetic (PBPK) models to understand the distribution of various drugs in the human body including a recent paper on using nanoparticles for controlled drug in leukemia therapy. Another area of research activity is in the Biotransformation of Coal to Methane using a community of microorganisms. We are examining the kinetics of biodegradation of coal using lumped kinetic models and experiments with lab-scale reactors. These models and experiments will assist us in improving commercial scale Coal Bed Methane (CBM) processes via microbial enhancement."
- Dhurjati, P., D. Ramkrishna, M. C. Flickinger and G. T. Tsao, "A Cybernetic View of Microbial Growth: Modeling of Cells as Optimal Strategists", Biotechnology and Bioengineering 27, 1, (1985)
- Petti, T. F., J. Klein and P. Dhurjati, "The Diagnostic Model Processor - Using Deep Knowledge for Process Fault Diagnosis", AIChE Journal 36, 565, (1990)
- Tokatlidis, K., S. Salamitou, P. Beguin, P. Dhurjati, J-P. Aubert, "Interaction of the Duplicated Segment carried by Clostridium thermocellumcellulases with cellulose components", FEBS Letters 291, 2, 185, (1991)
- Van Dyk, Tina K., W. R. Majarian, K. B. Konstantinov, R. M. Young, P. Dhurjati and R. LaRossa, "Rapid and sensitive pollutant detection by induction of heat shock gene-bioluminescence gene fusions", Applied and Environmental Microbiology 60, 1414, (1994)
- S. Saldanha, B. Bragdon, O. Moseychuk, J. Bonor, P. Dhurjati, A. Nohe,, "Caveolae Regulate Smad Signaling as Verified by Novel Imaging and System Biology Apporaches", Journal of Cell Physiology 228, 1060, (2013)
- Colin Heberling, Prasad Dhurjati and Myron Sasser, "Hypothesis for a systems connectivity model of autism spectral disorder pathogenesis: Link to gut bacteria, oxidative stress and intestinal permeability", Medical Hypotheses 80, 264, (2013)
- Sean G. Mack, Daniel J. Cook, Prasad Dhurjati, Matthew E. R. Butchbach, "Systems Biology Investigation of cAMP Modulation to increase SMN levels for the Treatment of Spinal Muscular Atrophy", PLoS One 9(12), (2014)
- Ryan Downs, Jonathon Perna, Andrew Vitelli, Daniel Cook, Prasad Dhurjati, "Model-based hypothesis of gut-microbe populations and gut/brain barrier permeabilities in the development of regressive autism", Medical Hypotheses 83, 649, (2014)
- MJ Gilkey, V. Krishan, L. Scheetz, X Jia, AK Rajasekaran, PS Dhurjati, "Physiologically Based Pharmacokinetic Modeling of Fluorescently Lableled Block Copolymer Nanoparticles for Controlled Drug Delivery in Leukemia Therapy", CPT Pharmacometrics and Systems Pharmacology (formerly Nature CPT-PSP) (2015)
- Bronson Weston, Benjamin Fogal, Daniel Cook, Prasad Dhurjati, "An agent-based modeling framework for evaluating hypotheses on risks for developing autism: Effects of the gut microbial environment", Medical Hypotheses (2015)
- NSF Presidential Young Investigator Award: 1986 - 1991
- Elected Fellow, American Institute of Medical and Biological Engineering
- College of Engineering Special Faculty Award