Prasad S Dhurjati
- Full Professor
University of Delaware
Newark, Delaware 19716
- Doctorate - 1982 Purdue University
- Bachelors - 1977 Indian Institute of Technology, Kanpur, India
"Our current research combines three decades of expertise in Biotechnology and Artificial intelligence. This research has resulted in over a hundred publications that have been cited over two thousand times with a H-index of 25. The top ten papers have been cited over 1000 times. The research has also resulted in the training of nearly 40 graduate students and post-doctoral research fellows (who are currently well placed in industry and academia) and over 60 undergraduate research students. The key research accomplishments are in the fields of Biochemical engineering and 'On-line fault diagnosis'. Current research is in the area of Systems Biology and Modeling of Engineering Systems. In biotechnology, we are currently applying mathematical models and knowledge-based approaches to convert biological and medical data to useful knowledge. In chemical process systems, we are analyzing on-line data using hybrid mathematical-heuristic approaches to diagnose faults. Common to both these application areas are the use of dynamic models, qualitative domain knowledge and artificial intelligence approaches for data interpretation and knowledge integration.
Our past research in biotechnology has resulted in a better understanding of microscopic and macroscopic variables that influence the Kinetics of genetically engineered microorganisms. The work from 1977 to 2000 in biochemical engineering was largely experimental. In joint research with the Pasteur Institute in Paris, Kostas Tokatlidis examined the effect of gene sequence and protein structure on the mechanism of inclusion body (protein aggregate) formation during high-level expression of cellulolytic proteins in recombinant cells. The papers from this work were cited nearly 300 times. As part of collaborative research with DuPont in environmental biotechnology, Konstantin Konstantinov (DuPont/Delaware) investigated the use of bioluminescent recombinant microorganisms as sensors for pollutants. The related paper has been cited 250 times.
A second major area of our research is Knowledge-Based Process Monitoring and Fault Diagnosis. In a joint project with Foxboro and DuPont (1982-86), we were involved in a pioneering effort for the first industrial application of an expert system, FALCON (Fault Analysis Consultant), for on-line fault diagnosis in a dynamic chemical process (DuPont adipic acid plant in Victoria, Texas). A key aspect of our work with intelligent monitoring and diagnostic systems is the exploitation of qualitative domain knowledge from heuristics as well as quantitative knowledge from mathematical models.
We are currently combining our past expertise in biotechnology and knowledge-based systems to examine novel applications in Systems Biology. In a joint project with Allan Shapiro in Plant Science, we developed a mathematical model of signaling pathways in Arabidopsis disease resistance. We have recently developed a systems connectivity model of Autism (Medical Hypotheses, 80, 264-270,(2013). Our goal is to develop system level models and tools for analysis and integration of information at various levels of hierarchy in biological systems. Our review article on Systems Biology (April 2008) points to the future direction of our research."
- Van Dyk, Tina K., W. R. Majarian, K. B. Konstantinov, R. M. Young, P. Dhurjati and R. LaRossa, "Rapid and sensitive pollutant detection by induction of heat shock gene-bioluminescence gene fusions", Applied and Environmental Microbiology 60, 1414, (1994)
- Tokatlidis, K., S. Salamitou, P. Beguin, P. Dhurjati, J-P. Aubert, "Interaction of the Duplicated Segment carried by Clostridium thermocellumcellulases with cellulose components", FEBS Letters 291, 2, 185, (1991)
- Petti, T. F., J. Klein and P. Dhurjati, "The Diagnostic Model Processor -Using Deep Knowledge for Process Fault Diagnosis", AIChE Journal 36, 565, (1990)
- Dhurjati, P., D. Ramkrishna, M. C. Flickinger and G. T. Tsao, "A Cybernetic View of Microbial Growth: Modeling of Cells as Optimal Strategists", Biotechnology and Bioengineering 27, 1, (1985)
- Michaud, D. J., A. G. Marsh, and P. S. Dhurjati, "eXPatGen: Generating dynamic expression patterns for the systematic evaluation of analytical methods", Bioinformatics 19(9), 1140, (2003)
- V. Agrawal, C. Zhang, A.D. Shapiro and P.S. Dhurjati, "A Dynamic Mathematical Model to Clarify Signaling Circuitry Underlying Programmed Cell Death Control in Arabidopsis Disease Resistance", Biotechnology Progress 20, 426, (2004)
- P. Dhurjati and R. Mahadevan, "Systems Biology: The synergistic interplay between biology and mathematics", Invited Lead Review Article, Canadian Journal of Chemical Engineering 86, 127, (2008)
- Robert Brendel and P. Dhurjati, "Design Methodology for screening dynamic characterisitcs of candidate heat-integrated flowsheets", Industrial & Engineering Chemistry Research 49, 9877, (2010)
- S. Saldanha, B. Bragdon, O. Moseychuk, J. Bonor, P. Dhurjati, A. Nohe,, "Caveolae Regulate Smad Signaling as Verified by Novel Imaging and System Biology Apporaches", Journal of Cell Physiology 228, 1060, (2013)
- Colin Heberling, Prasad Dhurjati and Myron Sasser, "Hypothesis for a systems connectivity model of autism spectral disorder pathogenesis: Link to gut bacteria, oxidative stress and intestinal permeability", Medical Hypotheses 80, 264, (2013)
- NSF Presidential Young Investigator Award: 1986 - 1991
- College of Engineering Special Faculty Award
- Elected Fellow, American Institute of Medical and Biological Engineering