University of Delaware - College of Engineering
CHEMICAL & BIOMOLECULAR ENGINEERING

People

Faculty

Christopher J Roberts

Christopher  Roberts
  • Full Professor
  • Director, Center for Biomanufacturing Science & Technology (CBST)

223 CLB
University of Delaware
Newark, Delaware 19716
cjr@udel.edu
302-831-0838
302-831-1048 (fax)


Education
  • Doctorate - 1999 Princeton University, Princeton, NJ
  • Masters - 1996 Princeton University, Princeton, NJ
  • Bachelors - 1994 University of Delaware

"Research in the Roberts lab is generally focused on quantitative prediction, design, and control of the physical stability of proteins from the perspective of biopharmaceutical products based upon therapeutic proteins and polypeptides. We combine experiments, modeling, and molecular theory across biochemical engineering, applied biophysics, and pharmaceutical sciences to address a range of topics that include: protein misfolding and aggregation; protein-protein and protein-excipient interactions; proteins at interfaces; high-concentration behavior and stability; and protein engineering create improved product properties. Additional details on each of the topics is available at the Research Group link above."

XSelected Publications

For a complete listing of publications, please view the Full CV.
  1. Andrews, J.M.; Roberts, C.J., "A Lumry-Eyring nucleated-polymerization model of protein aggregation kinetics", J. of Phys. Chem. 111, 7897, (2007)
  2. Roberts, C.J., "Nonnative protein aggregation kinetics", Biotech. Bioeng. 98, 927, (2007)
  3. LiY, Weiss, WF IV, Roberts, CJ, "Characterization of High Molecular-Weight Nonnative Aggregates and Aggregation Kinetics by Size Exclusion Chromatography with Inline Multi-Angle Laser Light Scattering", J. Pharm. Sci. 98, 3997, (2009)
  4. Top A, Roberts CJ*, Kiick KL*, "Conformational and aggregation properties of a PEGylated alanine-rich polypeptide", Biomacromolecules 12, 2184, (2011)
  5. Blanco MA, Sahin E, Li Y, Roberts CJ*, "Reexamining Protein-Protein and Protein-Solvent Interactions from Kirkwood-Buff Analysis of Light Scattering in Multi-Component Solutions", J Chem Phys 134, 1, (2011)
  6. Sahin E, Jordan JL, Zhang A, Naranjo A, Costanzo JA, Weiss WF IV, Spatara ML, Robinson AS, Fernandez EJ*, Roberts CJ, "Computational design and biophysical characterization of point mutations for gamma-Dcrystallin illustrate a balance conformational stability and intrinsic aggregation propensity", Biochemistry 50, 628, (2011)
  7. Brummitt RK, Nesta DP, Chang L, Chase SF, Laue TM, Roberts CJ, "Non-native aggregation of an lgG1 antibody in acidic conditions: 1. Unfolding, colloidal interactions, and formation of amyloid-like high molecular weight aggregates", J Pharm Sci 100, 2087, (2011)
  8. Kim N, Remmele RL, Liu D, Razinkhov V, Fernandez EJ, Roberts CJ, "Aggregationof Anti-Streptavidin Immunoglobulin Gamma-1 Mediated by Fab Unfolding and Competing Growth Pathways", Biophys Chem 172, 26, (2013)
  9. Roberts CJ, Nesta DP, Kim N, "Effects of temperature and osmolytes on parallel degradation routes for an IgG1 antibody", J Pharm Sci 102, 3556, (2013)
  10. Weiss WF IV, Zhang A, Jordan JL, Ivanova MA, Sahin E, Fernandez EJ, Roberts CJ, "Reduction of the C191-C220 disulfide of a-chymotrypsinogen A accelerates amyloid formation via reduced nucleation barriers", Biophys Chem 185, 79, (2014)

XPatents

XSelected Awards

For a complete listing of awards, please view the Full CV.
  1. Nominated for University Excellence-in-Teaching Award (University of Delaware: 2009)
  2. College of Engineering Excellence in Teaching Award (University of Delaware: 2008)
  3. Selected as one of the "Top Reviewers for the Journal of Pharmaceutical Sciences": 2007
  4. University of Kansas, American Association of Pharmaceutical Sciences (AAPS), Student Chapter, Pharmaceutics Lecturer: 2006
  5. New Investigator Grant (Pfizer Global Research & Development: 2005)
  6. AAPS New Investigator Award in Pharmaceutics and Pharmaceutical Technologies (AAPS: 2005)
  7. Ebert Prize (American Pharmacists Association: 2004)
  8. Merck Faculty Fellow (University of Delaware: 2004 - 2007)
  9. Barry M. Goldwater Scholarship: 1992


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