Christopher J Roberts

Christopher  Roberts
  • Associate Institute Director, National Institute for Innovation in Manufacturing of Biopharmaceuticals, USA
  • Full Professor
  • Director, Center for Biomanufacturing Science & Technology (CBST)

223 CLB
University of Delaware
Newark, Delaware 19716
302-831-1048 (fax)

  • Doctorate - 1999 Princeton University, Princeton, NJ
  • Masters - 1996 Princeton University, Princeton, NJ
  • Bachelors - 1994 University of Delaware

"Research in the Roberts lab is generally focused on quantitative prediction, design, and control of the physical stability of proteins from the perspective of biopharmaceutical products based upon therapeutic proteins and polypeptides. We combine experiments, modeling, and molecular theory across biochemical engineering, applied biophysics, and pharmaceutical sciences to address a range of topics that include: protein misfolding and aggregation; protein-protein and protein-excipient interactions; proteins at interfaces; high-concentration behavior and stability; and protein engineering create improved product properties. Additional details on each of the topics is available at the Research Group link above."

XSelected Publications

For a complete listing of publications, please view the Full CV.
  1. Perevozchikova T, Nanda H, Nesta DP, Roberts CJ, "Protein Adsorption, Desorption, and Aggregation Mediated by Solid-Liquid Interfaces", J Pharm Sci 104, 1946, (2015)
  2. Barnett GV, Razinkov V, Kerwin BA, Laue TM, Woodka A, Butler PD, Perevozchikova T, Roberts CJ, "Specific Ion Effects on the Aggregation Mechanisms and Protein-Protein Interactions for Anti-Streptavidin Immunoglobulin Gamma 1", J Phys Chem B 119, 5793, (2015)
  3. Roberts CJ, "Therapeautic Protein Aggregation: Mechanisms, Design and Control", Trends Biotech 32, 372, (2014)
  4. Blanco MA, Martorana E, Manno M, Perevozchikova T, Roberts CJ, "Protein-Protein Interactions in Dilute to Concentrated Solutions: Alpha-Chymotrypsinogen at Acidic pH", J Phys Chem B 118, 5817, (2014)
  5. Wu H, Kroe-Barrett R, Singh S, Robinson AS, Roberts CJ, "Competing Aggregation Pathways for Monoclonal Antibodies", FEBS Letters 588, 936, (2014)
  6. Blanco MA, Sahin E, Robinson AS, Roberts CJ, "Course-Grained Model of Protein-Protein Interactions, B22 and Protein Cluster Formation", J Phys Chem B 117, 16013, (2013)
  7. Roberts CJ, Das TK, Sahin E, "Predicting Aggregation Rates for Therapeutic Proteins: Approaches and Challenges", Int J Pharm 418, 318, (2011)
  8. Brummitt RK, Nesta DP, Chang L, Chase SF, Laue TM, Roberts CJ, "Non-native aggregation of an lgG1 antibody in acidic conditions: 1. Unfolding, colloidal interactions, and formation of amyloid-like high molecular weight aggregates", J Pharm Sci 100, 2087, (2011)
  9. Sahin E, Jordan JL, Zhang A, Naranjo A, Costanzo JA, Weiss WF IV, Spatara ML, Robinson AS, Fernandez EJ, Roberts CJ, "Computational design and biophysical characterization of point mutations for gamma-Dcrystallin illustrate a balance conformational stability and intrinsic aggregation propensity", Biochemistry 50, 628, (2011)
  10. Roberts, C.J., "Nonnative protein aggregation kinetics", Biotech. Bioeng. 98, 927, (2007)


XSelected Awards

For a complete listing of awards, please view the Full CV.
  1. Nominated for University Excellence-in-Teaching Award (University of Delaware: 2009)
  2. College of Engineering Excellence in Teaching Award (University of Delaware: 2008)
  3. Selected as one of the "Top Reviewers for the Journal of Pharmaceutical Sciences": 2007
  4. University of Kansas, American Association of Pharmaceutical Sciences (AAPS), Student Chapter, Pharmaceutics Lecturer: 2006
  5. New Investigator Grant (Pfizer Global Research & Development: 2005)
  6. AAPS New Investigator Award in Pharmaceutics and Pharmaceutical Technologies (AAPS: 2005)
  7. Merck Faculty Fellow (University of Delaware: 2004 - 2007)
  8. Ebert Prize (American Pharmacists Association: 2004)
  9. Barry M. Goldwater Scholarship: 1992

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