Kelvin H Lee

Kelvin Lee
  • Director, National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL)
  • Gore Professor of Chemical & Biomolecular Engineering

281 DBI
University of Delaware
Newark, Delaware 19716
302-831-1048 (fax)

  • Doctorate - 1995 California Institute of Technology
  • Masters - 1993 California Institute of Technology
  • Bachelors - 1991 Princeton University

"Proteomics and Systems Biology, Biomanufacturing, Alzheimer's disease

Our lab works on proteomics and genomics approaches applied to the manufacturing of biologics and to the diagnosis and treatment of Alzheimer's disease. Our work includes participation in the international CHO genome community to foster the open exchange of genome-scale data and information related to CHO cells - the platform technology used to manufacture more than $65 billion / year of medicines. We also work to apply proteomics methods to the discovery and establishment of diagnostic biomarkers for Alzheimer's disease and in the study of changes of cerebrospinal fluid proteins during passive immunization treatments for Alzheimer's disease. This work is facilitated by the development of models for the blood brain barrier."

XSelected Publications

For a complete listing of publications, please view the Full CV.
  1. P Gupta, KH Lee, "Silent Mutations Result in HlyA Hypersecretion by Reducing Intracellular HlyA Protein Aggregates.", Biotechnology and Bioengineering (2008)
  2. L Griffiths, LH Choe, KH Lee, KF Reardon, E Orton, "Protein Extraction and Two-Dimensional Gel Electrophoresis of Water-and Lipid-Soluble Proteins From Bovine Pericardium, a Low-Cellularity Tissue.", (2008)
  3. Lee D.H., Kim S.G., Park Y.C., Nam S.W., Lee K.H., Seo J.H., "Proteme analysis of recombinant Escherichia coli producing human glucagon-like peptides.", Journal of Chromatography 849, 323, (2007)
  4. Kuczenski R., Hong K., Garcia-Ojalvo J., Lee K.H., "Phosphorylated CLK can explain the delay in Drosophila circadian periodicity.", PLoS Computational Biology 3, e154, (2007)
  5. Lee K.H., Relkin N.R., "Reply: Cerebrospinal fluid biomarkers for Alzheimer's Disease.", Annals of Neurology 61, 497, (2007)
  6. DH Lee, SG Kim, YC Park, SW Nam, KH Lee and JH Seo, "Proteome analysis of recombinant Escherichia coli producing human glucagon-like peptide-1", Journal of Chromatography 849, 323, (2007)
  7. Finehout E.J., Franck Z., Choe L.H., Relkin N.R., Lee K.H., "Cerebrospinal Fluid Proteomic Biomarkers for Alzheimer's Disease.", Annals of Neurology 61, 120, (2007)
  8. Gupta P., Lee K.H., "Genomics and Proteomics in Process Development: Opportunities and Challenges.", Trends in Biotechnology 25, 324, (2007)
  9. Choe L.H., D'Ascenzo M., Relkin N.R., Pappin D., Ross P., Williamson B., Guertin S., Pribil P., Lee K.H., "8-Plex Quantification of changes in cerebrospinal fluid protein expression in subjects undergoing intravenous iimmunoglobulin treatment for Alzheimer's disease.", Proteomics 7, 3651, (2007)
  10. Aggarwal K., Choe L.H., Lee K.H., "Shotgun proteomics using the iTRAQ isobaric tags.", Briefings in Functional Genomics and Proteomics 5, 112, (2006)


  1. Porous Electrophoresis Sponges (5,637,202): California Institute of Technology, 1997
  2. Proteome Markers for Diagnosis of Alzheimer's Disease. (provisional patent application filed) ():

XSelected Awards

For a complete listing of awards, please view the Full CV.
  1. Gore Professor of Chemical Engineering (University of Delaware: 2007)
  2. Invited Participant in NSF New Century Scholars workshop, Stanford, California: 2006 - 2006
  3. Samuel C. and Nancy M. Fleming Professor of Molecular and Cell Biology (Cornell University: 2005 - 2005)
  4. Distinguished Professor, NYS Office of Science, Technology and Academic Research: 2004 - 2004
  5. Cornell Provost's Ronay and Richard Menschel Award for Distinguished Scholarship: 2004 - 2004
  6. Invited Participant in the National Academy of Engineering Frontiers of Engineering Symposium, Irvine, California: 2003 - 2003
  7. Camille Dreyfus Teacher-Scholar Award: 2003 - 2003
  8. Jay Bailey Young Investigator Best Paper Award in Metabolic Engineering: 2002 - 2002
  9. MIT Technology Review Top 100 Innovators in the World in Business & Technology: 2002 - 2002
  10. Invited Participant in the National Academy of Engineering Third German-American Frontiers of Engineering Symposium, Bremen, Germany.: 2000 - 2000

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