University of Delaware - College of Engineering
CHEMICAL & BIOMOLECULAR ENGINEERING

People

Faculty

Maciek R Antoniewicz

Maciek Antoniewicz
  • Associate Professor
  • DuPont Young Professor

211 CLB
University of Delaware
Newark, Delaware 19716
mranton@udel.edu
302-831-8960
302-831-1048 (fax)


Education
  • Doctorate - 2006 Massachusetts Institute of Technology, Cambridge MA
  • Masters - 2000 Delft University of Technology, Delft, The Netherlands
  • Bachelors - 1998 Delft University of Technology, Delft, The Netherlands

"The Antoniewicz lab for Metabolic Engineering and Systems Biology is focused on developing next generation tools for engineering microbial and mammalian cells applied to specific problems in biotechnology and medicine. Our current areas of focus include: 1) production of biofuels using microbes such as E. coli, yeast, and thermophiles; 2) the study and manipulation of mammalian cell phenotypes in diabetes.

Our research includes all modern technologies and techniques for molecular biology, metabolic flux analysis, cell biology, mass spectrometry, genomics, computer simulation and bioinformatics. The primary goal of our research is to provide a fundamental understanding of the function and regulation of complex biological processes that emerge through the interaction of genes, proteins, and metabolites at multiple metabolic and genetic regulatory levels. To achieve this, we develop novel experimental and computational tools to quantify cellular physiology and apply genome-wide models of cellular interactions to interpret the large sets of biological data generated from these technologies.

Our interests range from looking at model microbial systems, i.e. Saccharomyces cerevisiae, Escherichia coli and thermophiles, to investigations of mammalian cells such as hepatocytes, adipocytes and myocytes. Beyond large-scale identification of interactions and transcriptional control of network operations in isolated cells, we develop technologies for studying disease phenotypes at the whole organism level. Our results find applications in many areas including industrial biotechnology, e.g. metabolic engineering of microbial cells for the production of biofuels and biochemicals, and medicine, in particular, in the area of human (metabolic) disorders such as type-2 diabetes and cancer."

XSelected Publications

For a complete listing of publications, please view the Full CV.
  1. Antoniewicz MR, "13C metabolic flux analysis: optimal design of isotopic labeling experiments", Curr Opin Biotechnol (2013)
  2. Crown SB, Antoniewicz MR, "Parallel labeling experiments and metabolic flux analysis: Past, present and future methodologies", Metab Eng 16, 21, (2013)
  3. Antoniewicz MR, "Tandem mass spectrometry for measuring stable-isotope labeling", Curr Opin Biotechnol 24(1), 48, (2013)
  4. Ahn WS, Antoniewicz MR, "Parallel labeling experiments with [1,2-13C]glucose and [U-13C]glutamine provide new insights into CHO cell metabolism", Metab Eng 15, 34, (2013)
  5. Leighty RW, Antoniewicz MR, "Parallel labeling experiments with [U-13C]glucose validate E. coli metabolic network model for 13C metabolic flux analysis", Metab Eng 14(5), 533, (2012)
  6. Crown SB, Antoniewicz MR, "Rational design of 13C-labeling experiments for metabolic flux analysis in mammalian cells", BMC Syst Biol 6, 43, (2012)
  7. Choi J, Grossbach MT, Antoniewicz MR, "Measuring complete isotopomer distribution of aspartate using gas chromatography tandem mass spectrometry", Anal Chem 84(10), 4628, (2012)
  8. Ahn WS, Antoniewicz MR, "Towards dynamic metabolic flux analysis in CHO cell cultures", Biotechnology Journal 7(1), 61, (2012)
  9. Leighty RW, Antoniewicz MR, "Dynamic Metabolic Flux Analysis (DMFA): A Framework for Determining Fluxes at Metabolic Non-Steady State", Metab Eng 13(6), 745, (2011)
  10. Choi J, Antoniewicz MR, "Tandem mass spectrometry: a novel approach for metabolic flux analysis", Metab Eng 13(2), 225, (2011)

XPatents

XSelected Awards

For a complete listing of awards, please view the Full CV.
  1. Outstanding Junior Faculty Member, College of Engineering, University of Delaware: 2012
  2. National Science Foundation (NSF) Career Award: 2011 - 2016
  3. University of Delaware Research Foundation Strategic Initiatives Research Award: 2009 - 2011
  4. Emerging Leaders AllianceTraining Program (Invited Participant): 2008
  5. Jay Bailey Young Investigator Award for Best Paper in Metabolic Engineering: 2008
  6. University of Delaware Research Foundation Research Award: 2008
  7. DuPont Young Professor Award: 2008 - 2011
  8. DuPont-MIT Fellowship: 2001 - 2006
  9. Foundation Schuurman Schimmel & van Outeren National Scholarship, The Netherlands.: 1999 - 1999
  10. Foundation Vrijvrouwe van Renswoude National Scholarship, The Netherlands.: 1999 - 1999


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