Main Features of Metran

  • User-defined network models
  • Simulation of tracer experiments
  • Optimal experiment design
  • Theoretical yield calculations
  • Flux observability analysis

Screen Shots

Metran Screen Shots


Data and Models

Coming soon...

Download Metran

Please contact Prof. Antoniewicz via e-mail at to obtain METRAN.


Antoniewicz MR, Kelleher JK, Stephanopoulos G.
Elementary Metabolite Units (EMU): A novel framework for modeling isotopic distributions. Metab Eng 9(1): 68-86, 2007

Antoniewicz MR, Kelleher JK, Stephanopoulos G.
Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements. Metab Eng 8(4): 324-337, 2006

Young JD, Walther JL, Antoniewicz MR, Yoo H, Stephanopoulos G.
An Elementary Metabolite Unit (EMU) based method of isotopically nonstationary flux analysis. Biotechnol Bioeng, 2007

Yoo H, Antoniewicz MR, Stephanopoulos G, Kelleher JK.
Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line. J Biol Chem, 2008 (10.1074/jbc.M706494200)

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