Wilfred Chen

Gore Professor of Chemical Engineering

Department of Chemical and Biomolecular Engineering 

224 Colburn Lab, University of Delaware, Newark DE 19716

Phone: 302.831.6327
Fax: 302.831.1048

Proteins are the most versatile among the various biological building blocks. However, the strength of proteins - their versatility and specific interactions - also complicates and hinders their systematic design and engineering. Our lab has been interested in exploiting the modular nature of protein domains to design synthetic complexes that can perform new biological functions across different length scales. By adding logical and stimuli responsive components into the design, smart protein complexes can be created to sense and adapt to the constantly changing cellular environments. Research in our laboratory is focused on the development of new synthetic biology tools in connecting exchangeable protein domains into functional devices for applications in biocatalysis, biosensing, and therapeutics .

Latest publications

J. Vincent Price, Long Chen, W. Brian Whitaker, E. Terry Papoutsakis, and Wilfred Chen, Scaffoldless Engineered Enzyme Assembly for Enhanced Methanol Utilization, Proc. Natl. Acad. Sci. USA, 113, 12691-12696, 2016.

Qing Sun, Qi Chen, Daniel Blackstock, and Wilfred Chen, Post-translational modification of bio-nanoparticles as a modular platform for biosensor assembly, ACS Nano, 9, 8554-8561, 2015.

Qing Sun, Bhawna Madan, Shen-Long Tsai, Matthew P. DeLisa, and Wilfred Chen, Creation of artificial cellulosomes on DNA scaffolds by zinc finger protein-guided assembly for efficient cellulose hydrolysis, Chem. Comm., 50, 1423-1425, 2014.

Miso Park, Qing Sun, Fang Liu, Matthew P. DeLisa, and Wilfred Chen, Positional assembly of enzymes on bacterial outer membrane vesicles for cascade reactions, PLOS one, 9, e97103, 2014.



October 2016
We welcome a new graduate student, Daniel Yur, to the group

October 2016
A new paper on methanol conversion using synthetic enzyme cascade was published in PNAS link

September 2016
Dr. Chen selected as the 2017 winner of the ACS Marvin J. Johnson Award in Microbial and Biochemical Technology more

June 2016
We welcome two new graduate students, Alex Mitkas and Victoria Hunt, to the group

November 2015
We welcome a new graduate student, Rachel Lieser, to the group

September 2015
Dr. Chen selected as the 2015 winner of the Daniel I.C. Wang Award for Excellence in Biochemical Engineering

April 2015
Congratulations to Lauren for receiving this year NSF Graduate Fellowship.

We welcome a new graduate student, Andrew Gaynor, to the group

Open Positions
New opportunities in the lab - One Ph.D. student

Last Updated: April 19, 2016


Department of Chemical  and Biomolecular Engineering, Colburn Lab 224, University of Delaware, Newark, DE 19716

Maintained by Wilfred Chen