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Devesh Radhakrishnan

Devesh graduated with a Bachelors' degree in chemical engineering from the University of Mumbai in 2006 and a Masters' degree from the Indian Institute of Technology Bombay (IIT Bombay). Following a two year career as a scientist in the Research and Development division of Biocon, Ltd, where he worked on developing downstream purification strategies for recombinant human insulin and insulin analogs, he joined the graduate program at the University of Delaware in 2010. Devesh has a keen interest in learning languages, cultural geography, Carnatic music and environmentalism. In his spare time Devesh volunteers for The Indian Institute of Geographical Studies (TIIGS), Ek Titli - positive green news, and Asha for Education's Delaware chapter.

Research Description

The focus of this work is to develop an online strategy to control the product quality of recombinant biopharmaceuticals, specifically monoclonal antibodies (mAbs) produced in Chinese hamster ovary (CHO) cells. To do this, Devesh is working on developing a multi-scale model to describe the influence of bioreactor conditions as well as sub-cellular conditions on the glycosylation pattern in mAbs, which is a critical quality attribute determinant. The work will also involve the development of a state estimator and a multivariate controller in order to control the glycosylation pattern in mAbs.

Research Interests

Publications

Thesis Advisors

Babatunde A. Ogunnaike and Anne S. Robinson (Tulane University)