University of Delaware - College of Engineering



Wilfred Chen

Wilfred Chen
  • Gore Professor of Chemical Engineering

224 CLB
University of Delaware
Newark, Delaware 19716
302-831-1048 (fax)

  • Doctorate - 1993 California Institute of Technology
  • Bachelors - 1988 University of California, Los Angeles

"The complex interactions between humans and the biosphere have created some of our most challenging global problems in human history such as energy sustainability, environmental pollutions, and emergence or re-emergence of old and new epidemics and diseases. Research in my laboratory is focused on development of the next generation biomolecular tools in addressing these key global problems in viral infection, disease pathogenesis, biofuel production, and separation of protein pharmaceutics."

XSelected Publications

For a complete listing of publications, please view the Full CV.
  1. Daniel Blackstock and Wilfred Chen, "Halo-tag mediated self-labeling of fluorescent proteins to molecular beacons for nucleic acid detection", Chem. Comm. 50, 13735, (2014)
  2. Qing Sun, Bhawna Madan, Shen-Long Tsai, Matthew P. DeLisa, and Wilfred Chen, "Creation of artificial cellulosomes on DNA scaffolds by zinc finger protein-guided assembly for efficient cellulose hydrolysis", Chem. Comm. 50, 1423, (2014)
  3. Miso Park, Qing Sun, Fang Liu, Matthew P. DeLisa, and Wilfred Chen, "Positional assembly of enzymes on bacterial outer membrane vesicles for cascade reactions", PLOS one 9, e97103, (2014)
  4. Shen-Long Tsai, Nancy A. DaSilva, and Wilfred Chen, "Functional display of complex cellulosomes on the yeast surface via adaptive assembly", ACS Synthetic Biology 2, 14, (2013)
  5. Divya Sivaraman, Hsiao-Yun Yeh, Ashok Mulchandani, Marylynn V. Yates and Wilfred Chen, "Use of flow cytometry for the rapid and quantitative detection of poliovirus-infected cells via TAT peptide-delivered molecular beacons", Appl. Environ. Microbiol. 79, 696, (2013)
  6. Fang Liu, Scott Banta, and Wilfred Chen, "Functional assembly of a multi-enzyme methanol oxidation cascade on a surface-displayed trifunctional scaffold for enhanced NADH production", Chem. Comm. 49, 3766, (2013)
  7. Fang Liu, Shen-Long Tsai, Bhawna Madan, and Wilfred Chen, "Engineering a high-affinity scaffold for non-chromatographic protein purification via intein-mediated cleavage", Biotechnol. Bioeng. 2835, (2829)
  8. Payal Biswas, Lakshmi N Cella, Seung Hyun Kang, Ashok Mulchandani, Marylynn V. Yates, and Wilfred Chen, "A quantum-dot based protein module for in vivo monitoring of protease activity through fluorescence resonance energy transfer", Chem. Comm. 5261, (5259)
  9. Shen-Long Tsai, Jeongseok Oh, Shailendra Singh, Ruizhen Chen, and Wilfred Chen, "Functional assembly of mini-cellulosomes on the yeast surface for cellulose hydrolysis and ethanol production", Appl. Environ. Microbiol. 6093, (6087)
  10. Hsiao-Yun Yeh, Marylynn V. Yates, Ashok Mulchandani, and Wilfred Chen, "Visualizing the dynamics of viral replication in living cells via TAT-peptide delivery of nuclease-resistant molecular beacons", Proc. Natl. Acad. Sci. USA 105, 17522, (2008)


XSelected Awards

For a complete listing of awards, please view the Full CV.
  1. Gore Professor of Chemical Engineering: 2011
  2. Fellows, American Institute for Medical and Biological Engineering (AIMBE): 2011
  3. AIChE Food, Pharmaceutical, and Bioengineering Division Plenary Session, Biochemical Engineering (Area 15c) Award: 2008
  4. UC Presidential Chair: 2006 - 2010
  5. Fellows, American Association for the Advancement of Science: 2006
  6. Invited Participant of the Fifth Annual U.S./Japan Frontiers of Engineering Symposum: 2005
  7. Invited Participant of the National Academy of Engineering's Fourth Annual Symposium on Frontiers of Engineering: 1998
  8. NSF Faculty Early Career Development Award: 1997

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