The Lenhoff group performs research that spans the fields of applied protein biophysics, thermodynamics, transport phenomena, colloid and interface science and separations processes. We are located in the Department of Chemical Engineering at the University of Delaware in Newark, DE.

Research Overview

The main goal of our research is to analyze, control and exploit molecular interactions involving proteins and colloidal particles. Nanochromatography system.The motivation is initially to obtain improved quantitative insights into existing processes, leading to more effective methods for designing and using them, but an auxiliary objective is to develop new products and operations. These themes bring together a diverse collection of research activities involving theoretical and experimental work dealing with both the fundamentals -- transport, kinetic and thermodynamic phenomena -- and their interaction in the process environment.

The path from molecular structure through continuum properties to process design represents the central paradigm in modern chemical engineering, Pipetters.but it has been applied much less extensively to species such as proteins than to small molecules; such processes as protein separations still depend very heavily on empirical methods for design and optimization. Most of our group's efforts are devoted to understanding the fundamentals of bioseparations, especially in chromatography and in separations driven by protein phase behavior, which are discussed individually on the Research page. However, our protein research is also directed towards other research projects, including work on membrane proteins, in conjunction with our relationship with the COBRE on Membrane Protein Production and Characterization. We have also worked on numerous other applications, ranging from fundamental fluid mechanics and mass transfer to colloidal adsorption to development of novel materials.